Very long non-coding RNA and human disease
β Scribed by Chan, Wen-Ling; Chang, Ya-Sian; Yang, Wen-Kuan; Huang, Hsien-Da; Chang, Jan-Gowth
- Book ID
- 122789599
- Publisher
- EDP Sciences
- Year
- 2012
- Tongue
- English
- Weight
- 365 KB
- Volume
- 2
- Category
- Article
- ISSN
- 2211-8020
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The most well-studied sequences in the human genome are those of protein-coding genes. However, the coding exons of these genes account for only 1.5% of the genome, a proportion that increases to 2% if untranslated regions (UTRs) are considered 1 . In recent years, it has become increasingly apparen
Common themes are emerging in the molecular mechanisms of long non-coding RNA-mediated gene repression. Long non-coding RNAs (lncRNAs) participate in targeted gene silencing through chromatin remodelling, nuclear reorganisation, formation of a silencing domain and precise control over the entry of g