Very late activation antigen on synovial fluid T cells from patients with rheumatoid arthritis and other rheumatic diseases

✍ Scribed by A. Laffon; F. Sánchez-madrid; M. Ort Íz de Landázuri; A. Jim Énez Cuesta; A. Ariza; C. Ossorio; P. Sabando

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 591 KB
• Volume: 32
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/anr.1780320405

✦ Synopsis

We used flow cytometry and immunoprecipitation techniques to study the expression of the activation molecules transferrin receptor, interleukin-2 receptor, HLA-DR, and very late activation antigen 1 (VLA-1) on purified T lymphocytes from peripheral blood and synovial fluid of 9 patients with rheumatoid arthritis and 7 patients with other rheumatic diseases. We found a T cell subset bearing VLA-1 in synovial fluid from 8 rheumatoid arthritis patients and 4 patients with other rheumatic diseases. VLA-1 was not found in peripheral blood T lymphocytes from either group.

Antigen or mitogen stimulation of resting T lymphocytes results in T cell proliferation accompanied by the acquisition of various effector functions. In the course of T cell activation, a number of cell surface glycoproteins are newly expressed and follow a distinct kinetic pattern of appearance. Some molecules, such as interleukin-2 receptors (IL-2R), transferrin receptors (TrR), insulin receptors, 4F2, and early activation antigen 1, appear early, even before DNA synthesis (1-5). Others, such as HLA-DR, CB.1, Ta,, T lineage-specific activation antigen 1 (TLiSA-l), and