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Very High Risk of Cancer in Familial Peutz-Jeghers Syndrome

✍ Scribed by Francis M. Giardiello*; †; Jill D. Brensinger*; Anne C. Tersmette§; Steven N. Goodman†; Gloria M. Petersen†; ‖; Susan V. Booker†; Marcia Cruz-Correa; Johan A. Offerhaus†


Book ID
119755990
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
185 KB
Volume
119
Category
Article
ISSN
0016-5085

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Germline mutations in the STK11 gene have been identified in 10-70% of patients with Peutz-Jeghers syndrome (PJS), an autosomal-dominant hamartomatous polyposis syndrome. A second locus was assumed in a large proportion of PJS patients. To date, STK11 alterations comprise mainly point mutations; onl