✦ LIBER ✦

Vertebral osteophyte formation in experimental disc degeneration

✍ Scribed by Dr. Stephen J. Lipson; Helen Muir

Book ID: 102752097
Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 624 KB
Volume: 23
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780230309

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Experimental intervertebral disc degeneration produced in rabbits by ventral nuclear herniation reliably produces vertebral osteophytes. Osteophytes arise from proliferating inner annular fibers which undergo metaplasia into cartilage, calcify, and proceed through an endochondral ossification sequence. Proteoglycans extracted from the osteophytes reveal that the degree of aggregation, molecular size of the monomer, and the chondroitin sulfate/keratin sulfate ratio are directly related to the cartilage state of the tissue.

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