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Versatile kinetic approach to analysis of dissolution data

โœ Scribed by Peter Veng Pedersen; James W. Myrick

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
662 KB
Volume
67
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

A new kinetically based dissolution equation is presented that considers dissolution of polydisperse systems and disintegrating solid dosage forms. The equation is applicable under sink as well as nonsink conditions and enables the specific dissolution rate parameter, the dispersion parameter, the disintegration lag time, and a newly introduced parameter, the dissolution availability, to be evaluated simultaneously and directly from percent of label claim dissolved versus time data. The equation showed excellent fit to dissolution data for aminophylline tablets. The kinetic significance of the estimated parameters of the equation is discussed. The method of analysis is compared to an approach employing an empirical equation based on a modified Weibull distribution function.

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