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Versatile inducible activation system of Akt/PKB signaling pathway in mice

✍ Scribed by Jens Kroll; Patricia Cobo; Thomas N. Sato

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
138 KB
Volume
35
Category
Article
ISSN
1526-954X

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✦ Synopsis

Abstract

Summary: We report a transgenic mouse line in which Akt/protein kinase B (PKB) pathway can be activated in an inducible manner in defined cell types. In this transgenic mouse line, Cre expression allows the expression of a tamoxifen‐activatable form of Akt/PKB in a defined cell type. Subsequent injection of tamoxifen triggers the transient activation of Akt/PKB in mice. Thus, this transgenic line allows the transient activation of Akt/PKB pathway in a predefined cell type. We expect that this transgenic system will provide a unique tool to study the roles of Akt/PKB pathway in mice. genesis 35:160–163, 2003. © 2003 Wiley‐Liss, Inc.

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