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Versatile and Stereoselective Synthesis of Diamino Diol Dipeptide Isosteres, Core Units of Pseudopeptide HIV Protease Inhibitors

โœ Scribed by Benedetti, Fabio; Miertus, Stanislav; Norbedo, Stefano; Tossi, Alessandro; Zlatoidzky, Pavel


Book ID
126937364
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
204 KB
Volume
62
Category
Article
ISSN
0022-3263

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โœ Alessandro Dondoni; Daniela Perrone ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 228 KB

The synthesis of the pseudo C2-symmetric dibenzyldiamino alcohol (S,S)-I and the two meso stereoisomers la and lb (R = PhCH2) is described by stereocontrolled benzylmagnesium chloride addition to the nitrones 3 derived from chiral ~-amino-c~-hydroxy aldehydes 2 that in turn were obtained from phenyl