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Vero cell-expressed Epstein-Barr virus (EBV) gp350/220 protects marmosets from EBV challenge

✍ Scribed by Dr. Emilio A. Emini; William A. Schleif; Melvin Silberklang; Dale Lehman; Ronald W. Ellis

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 378 KB
Volume: 27
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890270210

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✦ Synopsis

The Epstein-Barr virus (EBV) major membrane antigen, gp3501220, was purified from expressing, genetically engineered Vero cells. The antigen, formulated either with alum or Freund's adjuvant, was inoculated into EBV infection-susceptible marmosets. After several injections, most of the marmosets developed anti-gp350/ 220 antibodies, and several exhibited virus-neutralizing activity. The immune response elicited by the alum-adsorbed antigen proved to be protective upon virus challenge of the inoculated animals. Protection did not correlate with the presence of neutralizing antibodies.

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