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Verification of a Designed Intramolecular Hydrogen Bond in a Drug Scaffold by Nuclear Magnetic Resonance Spectroscopy

โœ Scribed by Jansma, Ariane; Zhang, Qiong; Li, Bing; Ding, Qiang; Uno, Tetsuo; Bursulaya, Badry; Liu, Yi; Furet, Pascal; Gray, Nathanael S.; Geierstanger, Bernhard H.


Book ID
120825863
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
82 KB
Volume
50
Category
Article
ISSN
0022-2623

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2imitingn 'H and I5 Y chemical shifts for the imino moiety of C in the GC .base pair were evaluated in model studies using chlorofomn sotuhle 2', 3 '-O-isopronqlidene-5 '-O-tbutytdimethylsilyl derivatives and uere found to be significantl!r dolJrZfield from previously reported shifts measured in dim