✦ LIBER ✦
Vergleichende Untersuchung zur Diastereoselektivität derO-Methylierung von sterisch behinderten β-Ketocarbonsäureestern und ihren Enolen
✍ Scribed by Buß, Monika ;Meier, Herbert
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 216 KB
- Volume
- 1990
- Category
- Article
- ISSN
- 0947-3440
No coin nor oath required. For personal study only.
✦ Synopsis
Diastereoselectivity of the O‐Methylation of Sterically Hindered β‐Ketocarboxylates and Their Enols
The enols 1a, b, and 1c, which exists almost completely in the keto form, have been methylated at the oxygen atom with diazomethane. The regioselective reaction can be catalyzed by methanol, but may loose in that case the diastereoselectivity. A comparison with the methylation of the enolates by iodomethane is discussed.