Veratrum Alkaloids XLIII**Received November 9. 1959, from the Department of Pharmaceutical Chemistry, University of Wisconsin. Madison.

✍ Scribed by Kupchan, S. Morris ;Afonso, Adriano

• Publisher: Elsevier
• Year: 1960
• Weight: 256 KB
• Volume: 49
• Category: Article
• ISSN: 0095-9553
• DOI: 10.1002/jps.3030490416

✦ Synopsis

1. The solubility of benzoic acid and aspirin as a function of pH, citrate concentratior?, and sodium chloride concentration has been determined. In addition, the effect of sodium acetate on the solubility of benzoic acid and the effect of concentration on the dissociation constants of citric acid were investigated.

The interaction of sodium acetate and benzoic acid closely followed the law of mass action. The citrate interactions deviated widely from such considerations; an actual decrease in solubility was observed a t high citrate concentrations. These results, however, are to be expected if the effect of ionic environment is taken into consideration.

Analysis of the acid-base interactions with the aid of other studies, pursued here and else-

where, suggests that complexing occurs to only a limited extent, if at all, except a t very high citrate concentrations where such associations may play a predominant role in the interactions.