protoverine 3-isobutyrate 6,7,16-triacetate 15-nicotinate (XVI) in 57 ml. of methanol was allowed to stand at room temperature for 16 hours. Evaporation to dryness left a resin which resisted attempts a t purification by column chromatography, but which yielded to preparative paper chromatography. T
Veratrum alkaloids L. Structure-activity relationships in a series of synthetic hypotensive analogs of the protoveratrines
✍ Scribed by S. Morris Kupchan; Eiichi Fujita; John C. Grivas; Lawrence C. Weaver
- Publisher
- John Wiley and Sons
- Year
- 1962
- Tongue
- English
- Weight
- 474 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0022-3549
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A clear-cut correlation between antimalarial potency and the restored in the C-5a-unsubstituted analog 8, bearing a methoxymethyl group at C-3. Reaction of 8 with Mn II TPP alkylative property of synthetic tricyclic trioxanes 5-10 is reported. Thus, trioxanes 5 and 7, substituted at the C-5a furnish
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