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Verapamil plasma binding: Relationship to α1-acid glycoprotein and drug efficacy

✍ Scribed by McGowan, Francis X; Reiter, Michael J; Pritchett, Edward L C; Shand, David G


Book ID
109843310
Publisher
Nature Publishing Group
Year
1983
Tongue
English
Weight
362 KB
Volume
33
Category
Article
ISSN
0009-9236

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We investigated the binding of propranolol (PL), disopyramide (DP), and verapamil (VP) enantiomers by human alpha(1)-acid glycoprotein (AGP; also called orosomucoid) and the relationships between the extent of drug binding and lipophilicity, desialylation, and genetic variants of AGP. Desialylation