Verapamil and cyclosporin a sensitize human kidney tumor cells to vincristine in absence of membrane P-glycoprotein and without apparent changes in the cytoplasmic free Ca2+concentration

Development of vincristine resistance an

Development of vincristine resistance and increased sensitivity to cyclosporin A and verapamil in the human U-937 lymphoma cell line without overexpression of the 170-KDa P-glycoprotein

✍ Johan Botling; Gunnar Liminga; Rolf Larsson; Peter Nygren; Kenneth Nilsson 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 767 KB

A vincristine (vcr)-resistant subline of the human histiocytic lymphoma cell line U-937 (U-937-vcr) has been established and characterized with respect to its phenotypic features, including growth rate, surface marker expression and ability to respond to differentiation-inducing agents. The sensitiv