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Ventx, a Novel Wnt Antagonist, Regulates Cellular Senescence in Cancer Cells

✍ Scribed by Gao, Hong (Jenny) ;Wu, Xiaoming ;Saltzman, John R. ;Zhu, Zhenglun (Jerry)

Book ID
123468381
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
60 KB
Volume
140
Category
Article
ISSN
0016-5085

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## Abstract Vascular endothelial growth factor (VEGF) inhibitors, such as bevacizumab, have improved outcomes in metastatic colorectal cancer (CRC). Recent studies have suggested that VEGF can delay the onset of cellular senescence in human endothelial cells. As VEGF receptors are known to be upreg