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Ventricular enlargement and mild cognitive impairment in early Parkinson's disease

✍ Scribed by Turi O. Dalaker; Robert Zivadinov; Deepa Preeti Ramasamy; Mona K. Beyer; Guido Alves; Kolbjorn S. Bronnick; Ole-Bjorn Tysnes; Dag Aarsland; Jan P. Larsen

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 96 KB
Volume: 26
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.23443

No coin nor oath required. For personal study only.

✦ Synopsis

Mild cognitive impairment (MCI) may predict future development of dementia in Parkinson's disease (PD). We aimed to examine the extent of subcortical brain atrophy in patients with early PD with and without MCI compared to normal controls (NC). Participating in a population-based study were 43 early, drugnaı ¨ve PD patients and 41 NC. Eleven patients were classified with MCI (MCI PD) and 32 patients without (non-MCI PD). Volumetric segmentation of 3D-T1 weighted brain MRI was performed using FreeSurfer. Groups were compared applying MANCOVA corrected for total intracranial volume, age, and sex. Results

showed that left inferior lateral ventricle and third ventricle volumes were significantly larger in MCI PD than in non-MCI PD and NC. Fourth ventricular size in MCI PD was significantly different from NC and highly correlated with memory performance in MCI PD patients. This suggests that cognitive dysfunction in early PD may be associated with ventricular enlargement. V

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