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Ventral pallidal injections of a mu antagonist block the development of behavioral sensitization to systemic morphine

โœ Scribed by Patricia I. Johnson; T. Celeste Napier


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
173 KB
Volume
38
Category
Article
ISSN
0887-4476

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AMPA antagonist LY293558 blocks the deve
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Morphine (3.0 mg/kg, SC) stimulates locomotor activity in rats, and this effect sensitizes with repeated intermittent treatment. We examined the ability of the AMPA antagonist LY293558, administered systemically over a range of doses (0.1-3.0 mg/kg), to alter morphine sensitization. Pretreatment wit