Veno-occlusive liver disease after dacarbazine therapy (DTIC) for melanoma

✍ Scribed by Christian Erichsen; Per-Ebbe Jönsson

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 286 KB
• Volume: 27
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930270415

✦ Synopsis

A case of veno-occlusive disease of the liver with fatal outcome after dacarbazine (DTIC) therapy for melanoma is reported. There was a fulminant clinical course from start of symptoms until death. At autopsy the liver was enlarged and firm with signs of venous congestion. Smalland medium-sized hepatic veins were blocked by thrombosis. Eosinophilic infiltrations were found around the vessels. Published cases from the literature are reviewed and pertinent features discussed.