Velour-lined silicone rubber as an artificial bladder material

✍ Scribed by Stanley, Theodore H. ;Lattimer, John K.

• Book ID: 102871539
• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 620 KB
• Volume: 6
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.820060605

✦ Synopsis

Abstract

An ideal material for an artifical urinary bladder has not yet been designed. In order to study the effects of long‐term exposure of urine to velour‐lined Silastic silicone rubber, seven 80% cystectomized sheep had their natural bladders replaced with a Dacron velour‐lined, Silastic prosthesis. Animals were sacrificed 1 week, 3, 6, 9, and 18 months postimplantation of their prosthesis.

While the luminal surface of the prosthesis one week after implantation had small isolated patches of epithelium on it none of the remaining animals had any evidence of tissue growth on this surface. No stones or calcifications were found on the luminal surface of the prostheis in any of the animals except the 18‐month survivor who had microscopic evidence of early calcification.

The convex (serosal) surface of all the artifical bladders was covered with a thick connective tissue layer. At 9 months a muscle layer was seen in this tissue and it was clear the prosthesis was acting as a scaffold around which regeneration of the natural bladder was taking place. At 18 months after implantation regeneration of the natural bladder was complete and the prosthesis remained as a functionless, crumpled, hard foreign body in the lumin of the new bladder.

It appears that velour‐lined Silastic silicone rubber though not ideal may be an effective artificial bladder material as long as it remains functional.