Velocity compaction time-of-flight mass spectrometer for mass range 1000–10 000 u
✍ Scribed by M. L. Muga
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 111 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1076-5174
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✦ Synopsis
Basic and clinical research in the biomedical sciences demands improved instrumentation for accurate measurement and reliable analysis. Velocity compaction ion focusing provides for enhanced mass resolution in timeof-flight ion mass analysis.
Velocity compaction ion focusing' in a pulsed timeof-flight (TOF) mass spectrometer selectively accelerates the ions in an iso-mass packet in such a manner as to give all ions a nearly equal final drift velocity. In this way the spatial distribution of ions within the iso-mass packets is 'frozen' and peak-to-peak adjacent-mass ion packets continue to separate during the final drift period with minimal overlap due to the initial Boltzmann distribution of velocities. Computer simulations of flight time trajectories for such an instrument with 2.0 m total flight path indicate that unit separation can be readily achieved for molecular weights as high as loo00 u.
The design of a velocity compaction focusing secondary ion mass spectrometer has been completed and prototype development is underway. A diagram of the instrument is depicted in Fig. 1.