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Velo-cardio-facial syndrome and psychotic disorders: Implications for psychiatric genetics

โœ Scribed by Chow, Eva W. C. ;Bassett, Anne S. ;Weksberg, Rosanna

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
643 KB
Volume
54
Category
Article
ISSN
0148-7299

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โœฆ Synopsis

Psychiatric disorders have been reported i n over 10% of patients with velo-cardio-facial syndrome (VCFS) in longterm follow-up. To further explore the behavioral and psychiatric findings associated with VCFS in adulthood, detailed clinical histories of two patients-one with VCFS who developed a psychotic illness, and one with schizophrenia who was found to have dysmorphological features associated with VCFS-are described in the current report. The observed overlap of physical and psychiatric symptoms in these two patients suggests that VCFS and psychotic disorders may share a pathogenetic mechanism. This could be consistent with a contig uous gene model for VCFS and psychosis, suggesting chromosome 22qll as a possible candidate region for genetic studies of schizophrenia. o 1994 wiley-Liss, Inc.

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