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VEGFgene alternative splicing: pro- and anti-angiogenic isoforms in cancer

✍ Scribed by P. M. Biselli-Chicote; A. R. C. P. Oliveira; E. C. Pavarino; E. M. Goloni-Bertollo

Book ID: 106124478
Publisher: Springer-Verlag
Year: 2011
Tongue: English
Weight: 379 KB
Volume: 138
Category: Article
ISSN: 1432-1335
DOI: 10.1007/s00432-011-1073-2

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## Abstract Deregulation of protein synthesis plays a critical role in cell transformation. Several translation initiation factors (eIFs) have been implicated in malignant transformation; thus, suppression of eIFs could be a potential cancer therapy if cancer cells are selectively killed without da