โ Scribed by Christiana Ruhrberg
No coin nor oath required. For personal study only.
This book is devoted to vascular endothelial growth factor A (VEGF or VEGFA), a secreted signalling protein of great significance for development and disease in vertebrates. VEGFA controls the proliferation, migration, specialisation and survival of vascular endothelial cells, and it is therefore essential for the establishment of a functional blood vessel circuit. In addition, VEGFA is emerging as a versatile patterning factor for several non-endothelial cell types in vertebrates. Thus, it plays a central role during organ development at multiple levels, including blood vessel growth, vessel-mediated organ induction and tissue differentiation.
Cover......Page 1
Copyright......Page 3
About the Editor......Page 4
Contents......Page 5
Contributors......Page 7
Preface......Page 9
Acknowledgments......Page 11
1. The Biology of Vascular Endothelial Cell Growth Factor Isoforms......Page 12
2. VEGF Receptor Signalling in Vertebrate Development......Page 25
3. VEGF Gene Regulation......Page 41
4. Embryonic Vasculogenesis and Hematopoietic Specification......Page 51
5. Role of VEGF in Organogenesis......Page 63
6. VEGF and Endothelial Guidance in Angiogenic Sprouting......Page 79
7. Vascular and Nonvascular Roles of VEGF in Bone Development......Page 90
8. VEGF in the Nervous System......Page 102
Index......Page 115
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