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VEGF-A165-INDUCED PROSTACYCLIN RELEASE REQUIRES THE HETERODIMERIZATION OF VEGFR-1 AND VEGFR-2 RECEPTORS

✍ Scribed by Paul-Eduard Neagoe; Martin G Sirois


Book ID
116342001
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
58 KB
Volume
13
Category
Article
ISSN
1054-8807

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VEGF165 mediates formation of complexes
✍ Shay Soker; Hua-Quan Miao; Masashi Nomi; Seiji Takashima; Michael Klagsbrun πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 336 KB

Co-expression of NRP1 and (VEGFR-2) KDR on the surface of endothelial cells (EC) enhances VEGF165 binding to KDR and EC chemotaxis in response to VEGF165. Overexpression of NRP1 by prostate tumor cells in vivo results in increased tumor angiogenesis and growth. We investigated the molecular mechanis