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Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

✍ Scribed by K-D. Fischer; Y-Y. Kong; H. Nishina; K. Tedford; L.E.M. Marengère; I. Kozieradzki; T. Sasaki; M. Starr; G. Chan; S. Gardener; M.P. Nghiem; D. Bouchard; M. Barbacid; A. Bernstein; J.M. Penninger

Book ID: 114321141
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 228 KB
Volume: 8
Category: Article
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(98)70224-6

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## Background: Vav is a guanine-nucleotide exchange factor for the rho-like small gtpases rhoa, rac1 and cdc42, which regulate cytoskeletal reorganization and activation of stress-activated protein kinases (sapk/jnks). vav is expressed in hematopoietic cells and is phosphorylated in t and b cells f

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