Vav: A potential link between tyrosine kinases and Ras-like GTPases in hematopoietic cell signaling

✍ Scribed by Patrick Hu; Ben Margolis; Joseph Schlessinger

• Book ID: 102760900
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 675 KB
• Volume: 15
• Category: Article
• ISSN: 0265-9247
• DOI: 10.1002/bies.950150306

✦ Synopsis

The vav proto-oncogene encodes a 95 kDa protein which is expressed exclusively in hematopoietic cells. Analysis of the deduced amino acid sequence has revealed the presence of a src-homology 2 (SH2) domain, 2 SH3 domains, a cysteine-rich region with similarity to protein kinase C, and a region highly similar to proteins with guanine nucleotide exchange activity on rus-like GTPases. Recent work has shown that vnv is tyrosine phosphorylated in response to stimulation of surface membrane receptors in a variety of' hematopoietic cell lines. Vnv may play a role in hematopoietic cell signaling by coupling tyrosine kinase pathways to ras-like GTPases through the regulation of guanine nucleotide exchange.