Seven new cyclic peptides, cyclosquamosins A -G (1 -7), have been isolated from the seeds of Annona squamosa. Their structures and conformation of cyclosquamosin A in solution were elucidated by extensive 2D NMR methods and chemical degradation.
✦ LIBER ✦
Vasorelaxant activity of cyclic peptide, cyclosquamosin B, from Annona squamosa
✍ Scribed by Hiroshi Morita; Toru Iizuka; Chee-Yan Choo; Kit-Lam Chan; Koichi Takeya; Jun’ichi Kobayashi
- Book ID
- 108074063
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 178 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0960-894X
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We report the parallel synthesis of two natural cyclopeptides, isolated from the seeds of Annona squamosa, cyclosquamosin D (A1), and Met-cherimolacyclopeptide B (B) and their analogs. All of the compounds were screened for anti-inflammatory activity by evaluating their inhibitory effects on the pro