𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Vasomotor reactivity in dementia of alzheimer type

✍ Scribed by Dr. R. Heun; V. A. Knappertz; And G. Krämer

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
532 KB
Volume
9
Category
Article
ISSN
0885-6230

No coin nor oath required. For personal study only.

✦ Synopsis

The objective of this study was to examine the cerebral blood flow and the vasomotor function of C0,-responsive intracerebral vessels in Alzheimer's disease. Patients met DSM-111-R criteria for dementia of Alzheimer type and had neither symptoms nor signs of cardiovascular or cerebrovascular disease. Blood flow velocities in both middle cerebral arteries (MCA) were recorded using transcranial Doppler sonography during hypercapnia, normocapnia and hypocapnia. Several psychometric tests were performed. Patients' age, disease duration and severity of dementia did not correlate with vasomotor reactivity. Exploratory analysis revealed that mean flow velocities under hypercapnia correlated with severity of dementia and with patient's age. This suggests that the disease process does not influence the autoregulative function of small resistance vessels as assessed by CO, challenge. However, the excess reduction 01' the highest flow velocities measured during maximal CO, stimulation indicates that the number of small capillaries are diminished, or alternatively that the diameters of these capillaries are reduced in Alzheimer's disease.

📜 SIMILAR VOLUMES

CT study in senile dementia of Alzheimer
CT study in senile dementia of Alzheimer type
✍ Kenichi Ueyama; Hiroshi Fukuzako; Tsuyoshi Fukuzako; Yoshirou Hokazono; Kouzou T 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 419 KB

We evaluated 14 patients with senile dementia of Alzheimer type (SDAT) and 15 age-matched normal elderly controls using psychological tests and computed tomography scans. The low-density rate (LDR) was used as an index of brain atrophy. SDAT patients had significantly higher scores on the Hasegawa D

Personality change in dementia of the Al
Personality change in dementia of the Alzheimer type
✍ P. A. Jacomb; A. F. Jorm 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 579 KB

Although cognitive impairment is the predominant feature of dementia, personality changes are also frequently reported. This study aimed to describe the nature of personality change in dementia of the Alzheimer type (DAT) and the relationship of this change to cognitive decline. An informant-based i

Total serum homocysteine in senile demen
Total serum homocysteine in senile dementia of Alzheimer type
✍ Andrew McCaddon; Gareth Davies; Peter Hudson; Stephen Tandy; Howard Cattell 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 129 KB 👁 1 views

Objective. The main hypothesis was that subtle vitamin B12 de®ciencies occur more commonly in senile dementia of Alzheimer type (SDAT) than in healthy elderly individuals, and may be revealed by elevated total serum homocysteine (tHcy). A subsidiary hypothesis was that such de®ciencies would be nutr

PROTON MAGNETIC RESONANCE SPECTROSCOPY I
PROTON MAGNETIC RESONANCE SPECTROSCOPY IN DEMENTIA OF ALZHEIMER TYPE
✍ REINHARD HEUN; SABINE SCHLEGEL; MECHTHILD GRAF-MORGENSTERN; JAROSLAV TINTERA; JO 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB 👁 1 views

Reduced N-acetyl aspartate (NAA) and increased myo-inositol (MI) levels have been reported in patients with dementia of Alzheimer type (DAT) in comparison with controls. We wished to assess the validity of these findings and to evaluate possible correlations of metabolite proportions with cognitive