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Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase

✍ Scribed by Caroline Wheeler-Jones; Robin Abu-Ghazaleh; Rosario Cospedal; Rebecca A Houliston; John Martin; Ian Zachary


Book ID
117108555
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
314 KB
Volume
420
Category
Article
ISSN
0014-5793

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## Abstract Using spontaneously hypertensive and aortic banded rats, we have shown that expression of myocardial osteopontin, an extracellular matrix protein, coincides with the development of heart failure and is inhibited by captopril, suggesting a role for angiotensin II (ANG II). This study tes