Recent studies have demonstrated that the p53 tumor suppressor gene plays an important role in controlling tumor angiogenesis. We examined the expression of p53 and vascular endothelial growth factor (VEGF), a well-characterized angiogenic inducer, together with microvessel density to investigate th
β¦ LIBER β¦
Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases
β Scribed by Christiane J. Bruns; Wenbiao Liu; Darren W. Davis; Raymond M. Shaheen; David J. McConkey; Michael R. Wilson; Corazon D. Bucana; Daniel J. Hicklin; Lee M. Ellis
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 531 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0008-543X
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Vascular endothelial growth factor (VEGF), which is one of the most potent angiogenic factors, has been shown to play a pivotal role in tumor angiogenesis, including hepatocellular carcinoma (HCC). The effects of VEGF are mediated mainly through two distinct receptors, flt-1 and KDR/ Flk-1. It has b