Vascular endothelial growth factor inhibition: Conflicting roles in tumor growth
โ Scribed by Madhi Saranadasa; Eunice S. Wang
- Book ID
- 116399500
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 357 KB
- Volume
- 53
- Category
- Article
- ISSN
- 1043-4666
No coin nor oath required. For personal study only.
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New blood vessel formation (angiogenesis) is a fundamental event in the process of tumor growth and metastatic dissemination. Hence, the molecular basis of tumor angiogenesis has been of keen interest in the field of cancer research. The vascular endothelial growth factor (VEGF) pathway is well esta
Tumor-derived vascular endothelial growth factor (VEGF)/ vascular permeability factor (VPF) plays an important role in neovascularization and the development of tumor stroma. Furthermore, VEGF receptors are over-expressed in the endothelial cells of tumor vasculature and almost non-detectable in the