Vascular Endothelial Growth Factor-C Upregulates Cortactin and Promotes Metastasis of Esophageal Squamous Cell Carcinoma
โ Scribed by Su, Chih-Ming; Su, Yen-Hao; Chiu, Ching-Feng; Chang, Yi-Wen; Hong, Chih-Chen; Yu, Yang-Hao; Ho, Yuan-Soon; Wu, Chih-Hsiung; Yen, Chia-Sheng; Su, Jen-Liang
- Book ID
- 126318432
- Publisher
- Springer
- Year
- 2014
- Tongue
- English
- Weight
- 1012 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1068-9265
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The purpose of this study was to investigate the expression of vascular endothelial growth factor (VEGF) -C in human esophageal squamous cell carcinomas to elucidate its role in lymph node metastasis and tumor progression. The expression of VEGF-C and flt-4 genes was examined in 5 esophageal carcino
## Abstract ## Background and Methods. VEGF proteins and their receptors are involved in tumor vessel neoformation. The third VEGF receptor, VEGFR3 (fltโ4) is important during both blood vessel development and lymphatic vessel formation. Because HNSCC preferentially metastasizes to regional lymph