## Abstract Our previous studies have implied that prostaglandins inhibit cell growth independent of cAMP. Recent reports, however, have suggested that prostaglandin arrest of the cell cycle may be mediated through protein kinase A. In this report, in order to eliminate the role of cβAMP in prostag
Variations in the length of S-phase related to the time cells are blocked at the G1-S interface
β Scribed by Francesca Carnevali; Domenico Mariotti
- Book ID
- 104708284
- Publisher
- Springer
- Year
- 1977
- Tongue
- English
- Weight
- 235 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0009-5915
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β¦ Synopsis
The inhibition of DNA synthesis with hydroxyurea or 5-fluorode-oxyuridine decreases the duration of S-phase of synchronously growing Chinese hamster cultures. - The observed drug effects are discussed in relation to an alteration of programmed DNA replication.
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Cultures of human amniotic fluid cells and fibroblasts were temporarily blocked by the replication inhibitors thymidine (dT) surplus, fluorodeoxyuridine (FdU), hydroxyurea (HU), or methotrexate uridine (MU). The respective arresting point at G1-S transition and the homogeneity of the blocked cell po