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Variations in cortisol sensitivity: The clinical implications of the polymorphisms in the glucocorticoid receptor gene

✍ Scribed by S.W.J. Lamberts


Book ID
116322504
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
80 KB
Volume
45
Category
Article
ISSN
8756-3282

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Glucocorticoid (GC) resistance can occur in a number of diseases. It can be either generalized (i.e., familial glucocorticoid resistance) or localized (i.e., asthma). In many cases, a reason for this resistance to steroids lies with mutations or polymorphisms present in the glucocorticoid receptor g