Variations in centromeric heterochromatin among patients with pre-malignant and malignant oral diseases

✍ Scribed by Bhavana J. Dave; Amit H. Trivedi; Siddharth G. Adhvaryu

• Book ID: 102278335
• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: French
• Weight: 480 KB
• Volume: 48
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910480313

✦ Synopsis

Polymorphism of heterochromatic regions of chromosomes I, 9 and I6 was studied in 60 oral cancer patients, in 40 patients with oral submucous fibrosis (OSMF) and in 60 normal healthy subjects. The size heteromorphism was significantly greater (p < 0.001) in chromosome I of the patients. Localization variants were also significantly more frequent among the patients (p < 0.05 for OSMF and < 0.001 for oral cancer patients). The C-band heteromorphism patterns remained comparable in OSMF and in oral cancer patients, with chromosome I being the most frequently involved. On correlating the tobaccolareca-nut chewing habit with the presence of C-band heteromorphism, we observed that C-band heteromorphism was present in 89% of the habit-free oral cancer patients and 80% of the OSMF patients with relatively shorter exposure to this habit, i.e. <5 years. This signifies that genetic factors are important in the causation of oral precancerous and cancerous conditions and that polymorphism of the heterochromatic regions does appear to play a role in these conditions.

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