In this study we genotyped Turkish breast/ovarian cancer patients for BRCA1/BRCA2 mutations: protein truncation test (PTT) for exon 11 BRCA1 of and, multiplex PCR and denaturing gradient gel electrophoresis (DGGE) for BRCA2, complemented by DNA sequencing. In addition, a modified restriction assay w
Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene
β Scribed by Gayther, Simon A.; Mangion, Jonathon; Russell, Paul; Seal, Sheila; Barfoot, Rita; Ponder, Bruce A.J.; Stratton, Michael R.; Easton, Douglas
- Book ID
- 109914968
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 280 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1061-4036
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The two major hereditary breast/ovarian cancer predisposition tumor suppressor genes, BRCA1 and BRCA2 that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are altered, or mutated in the germline. However, little is known abo
Germline mutations in the BRCA1 and BRCA2 genes are responsible for the predisposition and development of familial breast and/or ovarian cancer. Most mutations of BRCA1 and BRCA2 associated with breast and/or ovarian cancer result in truncated proteins. To investigate the presence of BRCA1 and BRCA2