Variation of PDGF, TGFβ, and bFGF levels in essential thrombocythemia patients treated with anagrelide

PDGF-A, PDGF-B, TGFβ, and bFGF mRNA leve

PDGF-A, PDGF-B, TGFβ, and bFGF mRNA levels in patients with essential thrombocythemia treated with anagrelide

✍ Paola R. Lev; Juan P. Salim; Laura I. Kornblihtt; Carlos J. Pirola; Rosana F. Ma 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 61 KB

Plasmatic levels of PDGF-AB, TGFb 1 , and bFGF are increased in patients with essential thrombocythemia (ET) while intraplatelet levels are low for PDGF, normal for TGFb, and elevated for bFGF. To evaluate the contribution of gene expression to the dysregulated cytokine levels, we studied platelet P