Variation of functional MRI signal in response to frequency of somatosensory stimulation in α-chloralose anesthetized rats
✍ Scribed by Michael L. Gyngell; Christian Bock; Bernd Schmitz; Mathias Hoehn-Berlage; Konstantin-Alexander Hossmann
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 390 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0740-3194
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The dependence of functional MRI contrast on the repetition rate (1.5–9 Hz) of a sensory stimulus was investigated with a T~2~*‐weighted gradient echo method during forepaw stimulation of α‐chloralose anesthetized rats (n = 5). An activation area was observed in the left or right somatosensory cortex dependent on the stimulation of the right or left forepaw, respectively. The activation intensity decreased for stimulation frequencies above 3 Hz, and was negligible at 9 Hz. The interpretation is that at low stimulation rates the neurons can respond to each stimulus, but at higher rates there is insufficient recovery time so that the response is progressively occluded.