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Variation in the Uric Acid Transporter GeneSLC2A9and Its Association with AAO of Parkinson’s Disease

✍ Scribed by Maurizio F. Facheris; Andrew A. Hicks; Cosetta Minelli; Johann M. Hagenah; Vladimir Kostic; Susan Campbell; Caroline Hayward; Claudia B. Volpato; Cristian Pattaro; Veronique Vitart; Alan Wright; Harry Campbell; Christine Klein; Peter P. Pramstaller


Book ID
107575356
Publisher
Humana Press Inc
Year
2010
Tongue
English
Weight
122 KB
Volume
43
Category
Article
ISSN
0895-8696

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## Abstract The presynaptic dopamine transporter in nigral dopaminergic neurons confers susceptibility to the cytotoxic effects of the neurotoxic metabolite of 1‐methy1‐4‐phenyl‐1,2,3,6‐tetrahydropyridine. Polymorphisms in the dopamine transporter might influence the susceptibility to such toxins.