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Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation?

✍ Scribed by Harvey W. Mohrenweiser; Irene M. Jones

Book ID: 114072295
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 89 KB
Volume: 400
Category: Article
ISSN: 0027-5107
DOI: 10.1016/s0027-5107(98)00059-1

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## Abstract Variation in DNA repair capacity, which is believed to be largely determined by genetic traits, is linked to risk of certain cancers. The Asp312Asn and Lys751Gln polymorphisms in the xeroderma pigmentosum complementary group D (XPD) gene may alter DNA repair capacity. We thus examined t

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