Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder
✍ Scribed by Elaine K. Green; Detelina Grozeva; Valentina Moskvina; Marian L. Hamshere; Ian R. Jones; Lisa Jones; Liz Forty; Sian Caesar; Katherine Gordon-Smith; Christine Fraser; Ellie Russell; David St Clair; Allan H. Young; Nicol Ferrier; Anne Farmer; Peter McGuffin; Peter A. Holmans; Michael J. Owen; Michael C. O'Donovan; Nick Craddock
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 81 KB
- Volume
- 153B
- Category
- Article
- ISSN
- 1552-4841
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✦ Synopsis
Abstract
We have previously reported evidence that variation at GABA~A~ receptor genes is associated with susceptibility to bipolar disorder with schizophrenia‐like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene‐wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene‐wide P = 0.0058; experiment‐wide corrected significance P = 0.052). © 2010 Wiley‐Liss, Inc.