Variation across the allele frequency spectrum
โ Scribed by Gloyn, Anna L; McCarthy, Mark I
- Book ID
- 109916614
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 647 KB
- Volume
- 42
- Category
- Article
- ISSN
- 1061-4036
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Likelihood estimation and testing procedures are described for treating geographic variation in allelic frequencies as a logistic function of environmental variables. The basic response curve is sigmoidal, and avoids the necessity of invoking environmental thresholds imposed by a linear response mod
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The melanocortin 1 receptor (MC1R), a member of the G protein-coupled receptors superfamily, mediates the response to melanocortins and is currently the best-described contributor to normal pigment variation in humans. A remarkably large number of natural polymorphisms, or variants, of the MC1R gene