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Variant in PNPLA3 is associated with alcoholic liver disease

✍ Scribed by Tian, Chao; Stokowski, Renee P; Kershenobich, David; Ballinger, Dennis G; Hinds, David A

Book ID
109914542
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
154 KB
Volume
42
Category
Article
ISSN
1061-4036

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Nonalcoholic fatty liver disease (NAFLD) is a burgeoning medical problem that affects 20%-34% of the population in Western countries. 1 Although the prevalence of NAFLD is somewhat lower in Asia, the frequency is increasing, and the disorder is now being seen in younger individuals. 2,3 NAFLD is a m

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A recent genome-wide study revealed an association between variation in the PNPLA3 gene and liver fat content. In addition, the PNPLA3 single-nucleotide polymorphism rs738409 (M148I) was reported to be associated with advanced alcoholic liver disease in alcohol-dependent individuals of Mestizo desce

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The genetic factors associated with susceptibility to nonalcoholic fatty liver disease (NAFLD) in pediatric obesity remain largely unknown. Recently, a nonsynonymous single-nucleotide polymorphism (rs738409), in the patatin-like phospholipase 3 gene (PNPLA3) has been associated with hepatic steatosi