Variables predicting oral mucosal lesions in allogenic bone marrow recipients

✍ Scribed by Dr. Torsten Mattsson; Prof. Anders Heimdahl; Dr. Goran Dahllof; Dr. Bo Nilsson; Dr. Berit Lonnqvist; Prof. Olle Ringdén

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 538 KB
• Volume: 13
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.2880130311

✦ Synopsis

One hundred and forty-eight (72%) of 205 allogenic bone marrow transplant recipients developed rnucosal lesions in the oral cavity during the aplastic period after transplantation. Lesions were most frequent 8 to 9 days after transplantation. Factors that correlated with the development of mucosal lesions after univariate and multivariate analysis were a marrow cell dose of <3 x 10' cells/kg body weight, (p < O.OOOl), prolonged aplastic period (white blood cell count <0.2 x lo9 cell/l during more than 14 days @I < 0.005). herpes simplex virus-1 seropositivity of the recipient (p < 0.01), and conditioning with total body irradiation (p < 0.02). HEAD & NECK 1991;13:224-229 Complications after allogenic bone marrow transplantation (BMT) often originate in the oral cavity.'-3 Lesions in the oral mucosa increase the risk for local and systemic infections, cause pain and discomfort for the patient, and impair peroral nutrition. The patient often experiences From the Departments of Oral Surgery, (Dr. Mattsson and Prof. Heimdahl) Pedodontics, (Dr Dahllof), Cancer Epidemiology, (Dr. Nilsson),