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Variable pH kinetics: An easy determination of pH–rate profile

✍ Scribed by Giuseppe Alibrandi; Salvatore Coppolino; Norberto Micali; Antonino Villari

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
137 KB
Volume
90
Category
Article
ISSN
0022-3549

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✦ Synopsis

The complete pH-rate profile of the hydrolysis reaction of aspirin, requiring many experiments in the past, was obtained by a single variable-parameter kinetic experiment carried out by varying the hydrogen ion concentration. The experiment was carried out spectrophotometrically, reading automatically absorbance, pH, and temperature inside the reaction vessel. The results obtained by the fast processing of the kinetic profile are identical to those obtained under the same conditions but using traditional constant-pH kinetic runs. This method provides the possibility of reducing the amount of time and chemicals usually spent in collecting kinetic data in such mechanistic studies by nearly two orders of magnitude.

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