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Variable performance of commercial epidermal growth factor receptor antibodies in detection of basal-like breast cancer

✍ Scribed by Jennifer R Won; Dongxia Gao; Dennis Grant; James Cupples; Amir Rahemtulla; Robert Wolber; Torsten O Nielsen; Cyril B Gilks

Book ID
114729195
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
209 KB
Volume
61
Category
Article
ISSN
0309-0167

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Recent studies demonstrated that tumors overexpressing the epidermal growth factor receptor (EGF-R, erbB-1) are associated with poor clinical outcome. This led to the development of a variety of monoclonal antibodies targeting the extracellular domain of this receptor tyrosine kinase. The aim of our