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Variable Nanoparticle-Cell Adhesion Strength Regulates Cellular Uptake

✍ Scribed by Yuan, Hongyan; Li, Ju; Bao, Gang; Zhang, Sulin

Book ID: 121653447
Publisher: The American Physical Society
Year: 2010
Tongue: English
Weight: 467 KB
Volume: 105
Category: Article
ISSN: 0031-9007
DOI: 10.1103/PhysRevLett.105.138101

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## Abstract The purpose of this research project was to develop nanoparticles with improved targeting, adhesion, and cellular uptake to activated or inflamed endothelial cells (ECs) under physiological flow conditions. Our hypothesis is that by mimicking platelet binding to activated ECs through th