Variable modulation of opioid brain uptake by P-glycoprotein in mice
β Scribed by Claude Dagenais; Candace L. Graff; Gary M. Pollack
- Book ID
- 113486924
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 146 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0006-2952
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Low cerebral uptake of some therapeutic drugs can be enhanced by modulation of P-glycoprotein (P-gp), an ATP-driven drug efflux pump at the blood-brain barrier (BBB). We investigated the possibility of increasing cerebral uptake of the beta-adrenergic ligands S-1'-[(18)F]-fluorocarazolol (FCAR) and
To study the role of P-glycoprotein (P-gp) in the delivery of colchicine from blood to brain, the pharmacokinetics of colchicine in plasma and brain was studied in the rat by an in vivo method and by the in situ brain perfusion technique. Colchicine was administered intravenously at three doses (1,