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Variable manifestations in the short toes (s) mutation of the axolotl

✍ Scribed by Charles H. Washabaugh; Katia Del Rio-Tsonis; Panagiotis A. Tsonis

Book ID
102905308
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
826 KB
Volume
218
Category
Article
ISSN
0362-2525

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✦ Synopsis

Abstract

We describe a detailed histological analysis of the affected organs in the Short toes (s) mutation of the Mexican axolotl, Ambystoma mexicanum. The s mutant animals displayed a variation in the response to the mutation such as the time of death and the degree of abnormalities of the affected organs (limbs, kidney, ducts, and reproductive structures). In addition to the numerous histological abnormalities characterized here, we also examined the presence of laminin‐related molecules in s mutant kidney tissues to elucidate further the nature of the renal aplasia these animals encounter as a result of this recessive lethal mutation. Our data suggest that there may be a disruption in tissue interactions necessary for proper development and functioning of the affected tissues. Β© 1993 Wiley‐Liss, Inc.

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