Variable-ionic strength kinetic experiments in drug stability studies

✍ Scribed by Giuseppe Alibrandi; Salvatore Coppolino; Santi D'Aliberti; Paola Ficarra; Norberto Micali; Antonino Villari

• Book ID: 102396039
• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 78 KB
• Volume: 92
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.10422

✦ Synopsis

The dependence of the pseudo-first-order rate constant on the ionic strength for the alkaline hydrolysis of indomethacin has been obtained, for the first time, in a single kinetic experiment carried out by varying with time the salt concentration inside the reaction vessel. The kinetic profile obtained was processed using as a mathematical model the variable-parameter kinetic equation containing the Bronsted-Bjerrum equation as the dependence function. The results are in good agreement with those obtained by the traditional method but the experimental time is reduced to about one-tenth.